1.What is MGF- Mechano Growth Factor?
Mechano growth factor (MGF) is a variation of muscle insulin-like growth factor-1 (IGF-1) triggered by rigorous exercise and muscle damage. Structurally different than other growth factors such as IGF-1 that is synthesized by the liver, MGF enters muscle fibers to repair skeletal muscle tissue and prevent damaged cells from dying off. It adds stem cells into the muscle and is triggered by a pulse of stimulation after muscle tissues undergo significant mechanical stress. Genes for MGF are transcribed to a lesser degree as people age, which is why muscle mass decreases in the elderly, and certain diseases also interfere with the production of it. Supplements do not work as well for older people either because of the decrease in response to mechano growth factor.
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Product Name:MGF
Catalogue Number:L467890
Synonyms:Mechano Growth Factor,IGF-1Ec
CAS NO.: 108174-48-7
Molecular Formula:C121H200N42O39
Molecular Weight:2867.14
Sequence:H-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-His-Lys-NH2
One Letter Sequence:YQPPSTNKNTKSQRRKGSTFEEHK-NH2
Source:Chemical Synthesis
2.What is the Difference Between mechano growth factor and IGF-1
The difference between mechano growth factor and IGF-1 is that a group of carbon molecules at the end of the protein, called a C-terminus, controls the release of signals that trigger secretion. When muscles are damaged, MGF is activated, triggers the formation of additional proteins, and enables healthy muscle cell nuclei to form into new tissues and muscle fibers. A more systemic type of insulin-like growth factor from the liver is also produced in higher quantities, aiding in the longer term repair process of muscles.
3. Effects of MGF - Mechano Growth Factor
MGF is being used successfully by bodybuilders, for bringing up lagging body parts as well as overall growth. The most relevant rodent data has been shown that MGF is a very potent inducer of muscle growth when it is introduced into the muscle via an intramuscular injection of cDNA. In fact, in one study MGF caused a 20% increase in the weight of the injected muscle within 2 weeks. Further investigation elucidated that this was actually due to an increase in the size of the muscle fibers
4. Mechano Growth Factor (MGF) Dosage:
The recommended measure is 100-200mcg day by day. Peptide is best directed at least twice each day, bi-lateral dosages this will benefit to keep blood levels regular in your needed system, in cellular culture, or in vitro.
5. Why PEGylated MGF is better
MGF exhibits local effects in skeletal muscle and without modification is not systemic(can’t travel through the body). The problem with synthetic MGF is that it is introduced IM and is water based so it goes into the blood stream. MGF is not stable in the blood stream for more than a matter of minutes. Biologically produced MGF is made locally and does not enter the bloodstream and is short acting so stability is not an issue. By PEGylating the MGF we can make synthetic MGF injected IM almost as efficient as local produced MGF. Clinically proven Advanced Pegylation, the technology of polyethylene glycol (PEG) conjugation, holds significant promise in maintaining effective plasma concentrations of systemically administered drugs. It does this by surrounding part of the peptide with a unique structure made of polyethylene glycol,which can be attached to a protein molecule. The result of a correct PEGylation is simlarto the protective mechanism of a turtle shell. The polyethylene glycol groups protect the peptide but don’t surround it completely. The active sites of the peptide are still free to do their biological function. In this case the shell is a negative charged shield against positively charged compounds that would affect the protein. This also provides a nice steric chamber for the peptide to reside in. So it’s a happy turtle.Neurological research has shown that utilizing PEGylated MGF resulted in a longer more stable acting version of the MGF peptide in serum/blood.
Bottom line
PEGylation can improve performance and dosing convenience of peptides, proteins,antibodies, oligonucleotides and many small molecules by optimizing pharmacokinetics,increasing bioavailability, and decreasing immunogenicity and dosing frequency.PEGylation also can increase therapeutic efficacy by enabling increased drug concentration, improved biodistribution, and longer dwell time at the site of action. As a result, therapeutic drug concentrations can be achieved with less frequent dosing significant benefit to patients who are taking injected drugs.
The PEG itself does not react in the body and is very safe. PEG has been approved by the US Food and Drug Administration (FDA) as a base or vehicle for use in foods and cosmetics and in injectable, topical, rectal and nasal pharmaceutical formulations. PEG has demonstrated little toxicity, is eliminated intact by the kidneys or in the feces and lacks immunogenicity. The risk associated with current PEGylated drugs are due to the way the drug itself acts not the PEG. MGF, as it is being currently sold, is getting a bad rep from people due to the fact they feel that they are not seeing gains from it. Many people believe that the use of MGF in their cycles or protocols just flat out won't work,however, this is far from the truth.Here it is plain and simple for you. Without any complex peptide understanding required other than the fact that PEGylation increases the stability, and lifetime of the peptide.MGF is responsible for increasing muscle stem cell count through a process called proliferation.As you see the effect going left to right here is exponential. The more stem cells you have the more that can be stimulated and replicated. In order to signal this replication there has to be sufficient saturation of cell receptors. Because attachment to a receptor is by simple probability, the more peptide and the more time the more probable a cell will reach saturation and begin to replicate.IF regular MGF has a shorter life span, it has a significantly smaller chance at saturating cells. It is not stable in the blood so its only real chance to bind is right at injection. If you calculate probability of binding via (time x concentration) and then PEG last appx 300 times longer, the probability of MGF having a significant effect is about 300 times at the same dosage. In other words you would need 300 times the regular MGF to bind to as many receptors as the PEGylated version. And even at that case the loss of peptide to the blood so fast would still limit the effects of MGF.Now you must also consider the cumulative effects of having longer term MGF action.AS you saw in the image, the number of receptors will increase, this increase the probability further for the PEG version so now every time you undergo muscle stem cell replication within the 4-8 days the PEG version is active you increase the probability proportional to the increase in cell number.So without knowing anything more than multiplication and the law of probability one can see that PEG MGF is significantly more effective.
6. Storage for Mechano Growth Factor (MGF):
Dilute in STERILE WATER OR STERILE ACETIC ACID ONLY 1ml or 2mls per vial.If dilluted with STERILE WATER this peptide must be used within 7 to 10 days!If diluted with ACETIC ACID this peptide must be used within 21 days!Vials are freeze-dried and therefore will remain stable at room temperature for 1-2 months. However, for long term storage they should be kept a 2-8 degrees Celsius (refrigerator temperature), where they will remain stable for up to 18 months in powder form. Once mixed with mixing solution, vials should be stored in the refrigerator and not left at room temperature.
CAUTION:This product is NOT intended to prevent, treat, or cure disease conditions or to affect the structure or function of the body. The sale of this product is restricted to research applications ONLY. This product is NOT for human consumption. This product can be harmful if ingested. Picture may differ from actual product.
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